Symbol: Name: ID: |
FBXO11 F-box protein 11 GFS:3134 |
Gene name: | FBXO11 |
Chromosome: | 2p16.3 |
Previous Symbols: | |
Previous Names: | F-box only protein 11 |
Aliases: | FBX11, PRMT9, UBR6 |
Name Aliases: | ubiquitin protein ligase E3 component n-recognin 6 |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2147134 | Rat Genome Database ID: | RGD:727935 |
HGNC ID: | HGNC:13590 | RefSeq IDs: | NM_001190274 |
Entrez Gene ID: | 80204 | Ensembl Gene ID: | ENSG00000138081 |
VEGA IDs: | OTTHUMG00000129130 | UniProt ID: | Q86XK2 |
UCSC ID: | uc002rwe.2 | OMIM ID: | 607871 |
Pubmed: | PMID10531035 PMID 16487488 PMID 18162545 | ||
CCDS IDs: | CCDSCCDS1837.1 |
F-box only protein 11 is a protein that in humans is encoded by the FBXO11 gene.
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It can function as an arginine methyltransferase that symmetrically dimethylates arginine residues, and it acts as an adaptor protein to mediate the neddylation of p53, which leads to the suppression of p53 function. This gene is known to be down-regulated in melanocytes from patients with vitiligo, a skin disorder that results in depigmentation. Polymorphisms in this gene are associated with chronic otitis media with effusion and recurrent otitis media (COME/ROM), a hearing loss disorder, and the knockout of the homologous mouse gene results in the deaf mouse mutant Jeff (Jf), a single gene model of otitis media. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2010].
Function: Substrate recognition component of the a (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Binds to and neddylates phosphorylated p53/TP53, inhibiting its transcriptional activity. SCF(FBXO11) does not seem to direct ubiquitination of TP53
Products for FBXO11 gene
Catalog | Product Name | Application | Company |
GFS:E03134 | F-box protein 11; ELISA kit | ELISA | n/a |
GFS:A03134 | F-box protein 11; Anti | ANTIBODIES | n/a |
GFS:P03134 | F-box protein 11; Protien | Protien | n/a |