Symbol: Name: ID: |
CDK5RAP2 CDK5 regulatory subunit associated protein 2 GFS:7515 |
Gene name: | CDK5RAP2 |
Chromosome: | 9q33.3 |
Previous Symbols: | MCPH3 |
Previous Names: | microcephaly, primary autosomal recessive 3 |
Aliases: | C48, FLJ10867, CEP215 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2384875 | Rat Genome Database ID: | RGD:708451 |
HGNC ID: | HGNC:18672 | RefSeq IDs: | NM_001011649 |
Entrez Gene ID: | 55755 | Ensembl Gene ID: | ENSG00000136861 |
VEGA IDs: | OTTHUMG00000021043 | UniProt ID: | Q96SN8 |
UCSC ID: | uc004bkf.2 | OMIM ID: | 608201 |
Pubmed: | PMID10721722 PMID 17764569 | ||
CCDS IDs: | CCDSCCDS6823.1 CCDS CCDS43871.1 |
CDK5 regulatory subunit-associated protein 2 is a protein that in humans is encoded by the CDK5RAP2 gene.
Neuronal CDC2-like kinase, which is involved in the regulation of neuronal differentiation, is composed of a catalytic subunit, CDK5, and an activating subunit, p25NCK5A. The protein encoded by this gene binds to p25NCK5A and therefore may be involved in neuronal differentiation. The encoded protein may also be a substrate of neuronal CDC2-like kinase. Multiple transcript variants exist for this gene, but the full-length nature of only two has been determined. [provided by RefSeq, Jul 2008].
Function: Potential regulator of CDK5 activity via its interaction with CDK5R1. Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation (By similarity). Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter. Together with MAPRE1, it may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends.
Products for CDK5RAP2 gene
Catalog | Product Name | Application | Company |
GFS:E07515 | CDK5 regulatory subunit associated protein 2; ELISA kit | ELISA | n/a |
GFS:A07515 | CDK5 regulatory subunit associated protein 2; Anti | ANTIBODIES | n/a |
GFS:P07515 | CDK5 regulatory subunit associated protein 2; Protien | Protien | n/a |