Symbol: Name: ID: |
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 GFS:1751 |
Gene name: | TNFSF9 |
Chromosome: | 19p13.3 |
Previous Symbols: | |
Previous Names: | |
Aliases: | 4-1BB-L |
Name Aliases: | receptor 4-1BB ligand, |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1101058 | Rat Genome Database ID: | RGD:727974 |
HGNC ID: | HGNC:11939 | RefSeq IDs: | NM_003811 |
Entrez Gene ID: | 8744 | Ensembl Gene ID: | ENSG00000125657 |
VEGA IDs: | UniProt ID: | P41273 | |
UCSC ID: | uc002mfh.2 | OMIM ID: | 606182 |
Pubmed: | PMID8405064 PMID 8088337 | ||
CCDS IDs: | CCDSCCDS12169.1 |
The protein encoded by TNFSF9 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages.
Products for TNFSF9 gene
Catalog | Product Name | Application | Company |
GFS:E01751 | tumor necrosis factor (ligand) superfamily, member 9; ELISA kit | ELISA | n/a |
GFS:A01751 | tumor necrosis factor (ligand) superfamily, member 9; Anti | ANTIBODIES | n/a |
GFS:P01751 | tumor necrosis factor (ligand) superfamily, member 9; Protien | Protien | n/a |