Symbol: Name: ID: |
TNFSF15 tumor necrosis factor (ligand) superfamily, member 15 GFS:1744 |
Gene name: | TNFSF15 |
Chromosome: | 9q32 |
Previous Symbols: | |
Previous Names: | |
Aliases: | TL1, VEGI, TL1A, VEGI192A, MGC129934, MGC129935 |
Name Aliases: | vascular endothelial cell growth inhibitor, |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2180140 | Rat Genome Database ID: | RGD:628735 |
HGNC ID: | HGNC:11931 | RefSeq IDs: | NM_001204344 |
Entrez Gene ID: | 9966 | Ensembl Gene ID: | ENSG00000181634 |
VEGA IDs: | OTTHUMG00000021011 | UniProt ID: | O95150 |
UCSC ID: | uc004bjh.2 | OMIM ID: | 604052 |
Pubmed: | PMID9434163 | ||
CCDS IDs: | CCDSCCDS6809.1 |
Vascular endothelial growth inhibitor (VEGI) is an anti-angiogenic protein. It belongs to tumor necrosis factor (ligand) superfamily, where it is member 15. TNFSF15 is the human gene for it. The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis.
Products for TNFSF15 gene
Catalog | Product Name | Application | Company |
GFS:E01744 | tumor necrosis factor (ligand) superfamily, member 15; ELISA kit | ELISA | n/a |
GFS:A01744 | tumor necrosis factor (ligand) superfamily, member 15; Anti | ANTIBODIES | n/a |
GFS:P01744 | tumor necrosis factor (ligand) superfamily, member 15; Protien | Protien | n/a |