Symbol: Name: ID: |
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12 GFS:1739 |
Gene name: | TNFSF12 |
Chromosome: | 17p13.1 |
Previous Symbols: | |
Previous Names: | |
Aliases: | TWEAK, DR3LG, APO3L |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1196259 | Rat Genome Database ID: | RGD:1359620 |
HGNC ID: | HGNC:11927 | RefSeq IDs: | NM_003809 |
Entrez Gene ID: | 8742 | Ensembl Gene ID: | ENSG00000239697 |
VEGA IDs: | OTTHUMG00000108148 | UniProt ID: | O43508 |
UCSC ID: | OMIM ID: | 602695 | |
Pubmed: | PMID9405449 PMID 9560343 | ||
CCDS IDs: | CCDSCCDS11109.1 |
Tumor necrosis factor ligand superfamily member 12 is a protein that in humans is encoded by the TNFSF12 gene. The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine, which exists in both membrane-bound and secreted forms, can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. Alternative splicing results in multiple transcript variants. Some transcripts skip the last exon of this gene and continue into the second exon of the neighboring TNFSF13 gene; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. (provided by RefSeq) .
Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines.
Products for TNFSF12 gene
Catalog | Product Name | Application | Company |
GFS:E01739 | tumor necrosis factor (ligand) superfamily, member 12; ELISA kit | ELISA | n/a |
GFS:A01739 | tumor necrosis factor (ligand) superfamily, member 12; Anti | ANTIBODIES | n/a |
GFS:P01739 | tumor necrosis factor (ligand) superfamily, member 12; Protien | Protien | n/a |