Symbol: Name: ID: |
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b GFS:1741 |
Gene name: | TNFSF13B |
Chromosome: | 13q32-q34 |
Previous Symbols: | TNFSF20 |
Previous Names: | |
Aliases: | BAFF, THANK, BLYS, TALL-1, TALL1, CD257 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1344376 | Rat Genome Database ID: | RGD:1561519 |
HGNC ID: | HGNC:11929 | RefSeq IDs: | NM_001145645 |
Entrez Gene ID: | 10673 | Ensembl Gene ID: | ENSG00000102524 |
VEGA IDs: | OTTHUMG00000017329 | UniProt ID: | Q9Y275 |
UCSC ID: | uc001vqr.2 | OMIM ID: | 603969 |
Pubmed: | PMID10331498 PMID 10359578 | ||
CCDS IDs: | CCDSCCDS9509.1 CCDS CCDS45067.1 |
B-cell activating factor (BAFF) also known as tumor necrosis factor ligand superfamily member 13B is a protein that in humans is encoded by the TNFLSF13B gene. The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq].
Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.
Products for TNFSF13B gene
Catalog | Product Name | Application | Company |
GFS:E01741 | tumor necrosis factor (ligand) superfamily, member 13b; ELISA kit | ELISA | n/a |
GFS:A01741 | tumor necrosis factor (ligand) superfamily, member 13b; Anti | ANTIBODIES | n/a |
GFS:P01741 | tumor necrosis factor (ligand) superfamily, member 13b; Protien | Protien | n/a |