Symbol: Name: ID: |
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 GFS:1743 |
Gene name: | TNFSF14 |
Chromosome: | 19p13.3 |
Previous Symbols: | |
Previous Names: | |
Aliases: | LIGHT, LTg, HVEM-L, CD258 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1355317 | Rat Genome Database ID: | RGD:1588572 |
HGNC ID: | HGNC:11930 | RefSeq IDs: | NM_003807 |
Entrez Gene ID: | 8740 | Ensembl Gene ID: | ENSG00000125735 |
VEGA IDs: | UniProt ID: | O43557 | |
UCSC ID: | uc002mfk.1 | OMIM ID: | 604520 |
Pubmed: | PMID9462508 | ||
CCDS IDs: | CCDSCCDS12171.1 CCDS CCDS45939.1 |
Tumor necrosis factor ligand superfamily member 14 is a protein that in humans is encoded by the TNFSF14 gene. The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF14, which is a member of the tumor necrosis factor receptor superfamily, and which is also known as a herpesvirus entry mediator (HVEM). This protein may function as a costimulatory factor for the activation of lymphoid cells and as a deterrent to infection by herpesvirus. This protein has been shown to stimulate the proliferation of T cells, and trigger apoptosis of various tumor cells. This protein is also reported to prevent tumor necrosis factor alpha mediated apoptosis in primary hepatocyte. Two alternatively spliced transcript variant encoding distinct isoforms have been reported. [provided by RefSeq].
Cytokine that binds to TNFRSF3/LTBR. Binding to the decoy receptor TNFRSF6B modulates its effects. Activates NFKB, stimulates the proliferation of T-cells, and inhibits growth of the adenocarcinoma HT-29. Acts as a receptor for Herpes simplex virus.
Products for TNFSF14 gene
Catalog | Product Name | Application | Company |
GFS:E01743 | tumor necrosis factor (ligand) superfamily, member 14; ELISA kit | ELISA | n/a |
GFS:A01743 | tumor necrosis factor (ligand) superfamily, member 14; Anti | ANTIBODIES | n/a |
GFS:P01743 | tumor necrosis factor (ligand) superfamily, member 14; Protien | Protien | n/a |