Symbol: Name: ID: |
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13 GFS:1740 |
Gene name: | TNFSF13 |
Chromosome: | 17p13.1 |
Previous Symbols: | |
Previous Names: | |
Aliases: | APRIL, CD256 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1916833 | Rat Genome Database ID: | RGD:1305871 |
HGNC ID: | HGNC:11928 | RefSeq IDs: | NM_001198622 |
Entrez Gene ID: | 8741 | Ensembl Gene ID: | ENSG00000161955 |
VEGA IDs: | OTTHUMG00000108145 | UniProt ID: | O75888 |
UCSC ID: | OMIM ID: | 604472 | |
Pubmed: | PMID9743536 | ||
CCDS IDs: | CCDSCCDS11111.1 CCDS CCDS11112.1 CCDS CCDS42256.1 |
Tumor necrosis factor ligand superfamily member 13 (TNFSF13) also known as a proliferation-inducing ligand (APRIL) is a protein that in humans is encoded by the TNFSF13 gene. The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Alternative splicing results in multiple transcript variants. Some transcripts that skip the last exon of the upstream gene (TNFSF12) and continue into the second exon of this gene have been identified; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. (provided by RefSeq) .
Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA. May be implicated in the regulation of tumor cell growth. May be involved in monocyte/macrophage-mediated immunological processes.
Products for TNFSF13 gene
Catalog | Product Name | Application | Company |
GFS:E01740 | tumor necrosis factor (ligand) superfamily, member 13; ELISA kit | ELISA | n/a |
GFS:A01740 | tumor necrosis factor (ligand) superfamily, member 13; Anti | ANTIBODIES | n/a |
GFS:P01740 | tumor necrosis factor (ligand) superfamily, member 13; Protien | Protien | n/a |