Symbol: Name: ID: |
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 GFS:1737 |
Gene name: | TNFSF10 |
Chromosome: | 3q26 |
Previous Symbols: | |
Previous Names: | |
Aliases: | TRAIL, Apo-2L, TL2, CD253 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:107414 | Rat Genome Database ID: | RGD:628734 |
HGNC ID: | HGNC:11925 | RefSeq IDs: | NM_001190942 |
Entrez Gene ID: | 8743 | Ensembl Gene ID: | ENSG00000121858 |
VEGA IDs: | OTTHUMG00000156917 | UniProt ID: | P50591 |
UCSC ID: | uc003fid.2 | OMIM ID: | 603598 |
Pubmed: | PMID8777713 PMID 8663110 | ||
CCDS IDs: | CCDSCCDS3219.1 |
TNF-related apoptosis-inducing ligand (TRAIL), is a protein functioning as a ligand that induces the process of cell death called apoptosis. TRAIL has also been designated CD253 (cluster of differentiation 253). The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG. Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis.
Products for TNFSF10 gene
Catalog | Product Name | Application | Company |
GFS:E01737 | tumor necrosis factor (ligand) superfamily, member 10; ELISA kit | ELISA | n/a |
GFS:A01737 | tumor necrosis factor (ligand) superfamily, member 10; Anti | ANTIBODIES | n/a |
GFS:P01737 | tumor necrosis factor (ligand) superfamily, member 10; Protien | Protien | n/a |