Symbol: Name: ID: |
CASP8AP2 caspase 8 associated protein 2 GFS:4363 |
Gene name: | CASP8AP2 |
Chromosome: | 6q15 |
Previous Symbols: | |
Previous Names: | CASP8 associated protein 2 |
Aliases: | FLASH, CED-4, RIP25, FLJ11208, KIAA1315 |
Name Aliases: | FLICE-associated huge protein |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1349399 | Rat Genome Database ID: | RGD:1305771 |
HGNC ID: | HGNC:1510 | RefSeq IDs: | NM_001137667 |
Entrez Gene ID: | 9994 | Ensembl Gene ID: | ENSG00000118412 |
VEGA IDs: | OTTHUMG00000015212 | UniProt ID: | Q9UKL3 |
UCSC ID: | uc011dzz.1 | OMIM ID: | 606880 |
Pubmed: | PMID10235259 PMID 17245429 PMID 17003126 | ||
CCDS IDs: |
CASP8-associated protein 2 is a protein that in humans is encoded by the CASP8AP2 gene.
This protein is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the death-effector domain (DED) of caspase 8. Studies of FLASH protein suggested that this protein may be a component of the death-inducing signaling complex that includes Fas receptor, Fas-binding adapter FADD, and caspase 8, and plays a regulatory role in Fas-mediated apoptosis. Alternative splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, Nov 2008].
Function: Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF-kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase.
Products for CASP8AP2 gene
Catalog | Product Name | Application | Company |
GFS:E04363 | caspase 8 associated protein 2; ELISA kit | ELISA | n/a |
GFS:A04363 | caspase 8 associated protein 2; Anti | ANTIBODIES | n/a |
GFS:P04363 | caspase 8 associated protein 2; Protien | Protien | n/a |