Symbol: Name: ID: |
CASP10 caspase 10, apoptosis-related cysteine peptidase GFS:4284 |
Gene name: | CASP10 |
Chromosome: | 2q33-q34 |
Previous Symbols: | |
Previous Names: | caspase 10, apoptosis-related cysteine protease |
Aliases: | MCH4 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | Rat Genome Database ID: | ||
HGNC ID: | HGNC:1500 | RefSeq IDs: | NM_001230 |
Entrez Gene ID: | 843 | Ensembl Gene ID: | |
VEGA IDs: | OTTHUMG00000132818 | UniProt ID: | Q92851 |
UCSC ID: | uc002uxj.1 | OMIM ID: | 601762 |
Pubmed: | PMID8755496 | ||
CCDS IDs: | CCDSCCDS2338.1 CCDS CCDS2339.1 CCDS CCDS2340.1 |
Caspase-10 is an enzyme that, in humans, is encoded by the CASP10 gene.
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011].
Function: Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase-3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp- -AMC and Asp-Glu-Val-Asp- -AMC.
Function: Isoform C is proteolytically inactive.
Products for CASP10 gene
Catalog | Product Name | Application | Company |
GFS:E04284 | caspase 10, apoptosis-related cysteine peptidase; ELISA kit | ELISA | n/a |
GFS:A04284 | caspase 10, apoptosis-related cysteine peptidase; Anti | ANTIBODIES | n/a |
GFS:P04284 | caspase 10, apoptosis-related cysteine peptidase; Protien | Protien | n/a |