Symbol: Name: ID: |
CASP5 caspase 5, apoptosis-related cysteine peptidase GFS:4336 |
Gene name: | CASP5 |
Chromosome: | 11q22.2-q22.3 |
Previous Symbols: | |
Previous Names: | caspase 5, apoptosis-related cysteine protease |
Aliases: | ICE(rel)III |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | Rat Genome Database ID: | ||
HGNC ID: | HGNC:1506 | RefSeq IDs: | NM_001136109 |
Entrez Gene ID: | 838 | Ensembl Gene ID: | ENSG00000137757 |
VEGA IDs: | OTTHUMG00000048073 | UniProt ID: | P51878 |
UCSC ID: | uc010ruz.1 | OMIM ID: | 602665 |
Pubmed: | PMID7797592 PMID 9250871 | ||
CCDS IDs: | CCDSCCDS8328.2 CCDS CCDS44718.1 CCDS CCDS44719.1 CCDS CCDS44720.1 |
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc/Max/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein; this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Aug 2010].
Function: Mediator of programmed cell death (apoptosis).
Products for CASP5 gene
Catalog | Product Name | Application | Company |
GFS:E04336 | caspase 5, apoptosis-related cysteine peptidase; ELISA kit | ELISA | n/a |
GFS:A04336 | caspase 5, apoptosis-related cysteine peptidase; Anti | ANTIBODIES | n/a |
GFS:P04336 | caspase 5, apoptosis-related cysteine peptidase; Protien | Protien | n/a |