Symbol: Name: ID: |
CASP4 caspase 4, apoptosis-related cysteine peptidase GFS:4330 |
Gene name: | CASP4 |
Chromosome: | 11q22.2-q22.3 |
Previous Symbols: | |
Previous Names: | caspase 4, apoptosis-related cysteine protease |
Aliases: | ICE(rel)II, ICH-2, TX |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:107700 | Rat Genome Database ID: | RGD:621757 |
HGNC ID: | HGNC:1505 | RefSeq IDs: | NM_001225 |
Entrez Gene ID: | 837 | Ensembl Gene ID: | ENSG00000196954 |
VEGA IDs: | UniProt ID: | P49662 | |
UCSC ID: | uc001pid.1 | OMIM ID: | 602664 |
Pubmed: | PMID7797510 PMID 9250871 | ||
CCDS IDs: | CCDSCCDS8327.1 CCDS CCDS41704.1 |
This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008].
Function: Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves caspase-1.
Products for CASP4 gene
Catalog | Product Name | Application | Company |
GFS:E04330 | caspase 4, apoptosis-related cysteine peptidase; ELISA kit | ELISA | n/a |
GFS:A04330 | caspase 4, apoptosis-related cysteine peptidase; Anti | ANTIBODIES | n/a |
GFS:P04330 | caspase 4, apoptosis-related cysteine peptidase; Protien | Protien | n/a |