Symbol: Name: ID: |
CASP12 caspase 12 (gene/pseudogene) GFS:7806 |
Gene name: | CASP12 |
Chromosome: | 11q22.3 |
Previous Symbols: | CASP12P1 |
Previous Names: | caspase 12 pseudogene 1, "caspase 12" |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1312922 | Rat Genome Database ID: | RGD:621758 |
HGNC ID: | HGNC:19004 | RefSeq IDs: | XM_003118977 |
Entrez Gene ID: | 100506742 | Ensembl Gene ID: | ENSG00000204403 |
VEGA IDs: | OTTHUMG00000154965 | UniProt ID: | Q6UXS9 |
UCSC ID: | uc001pht.1 | OMIM ID: | 608633 |
Pubmed: | PMID12054529 PMID 9038361 PMID 16917906 PMID 16532395 | ||
CCDS IDs: |
Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. Several alternatively spliced transcript variants have been noted for this gene. (provided by RefSeq)
Function: Has no protease activity. May reduce cytokine release in response to bacterial lipopolysaccharide during infections. Reduces activation of NF-kappa-B in response to TNF.
Products for CASP12 gene
Catalog | Product Name | Application | Company |
GFS:E07806 | caspase 12 (gene/pseudogene); ELISA kit | ELISA | n/a |
GFS:A07806 | caspase 12 (gene/pseudogene); Anti | ANTIBODIES | n/a |
GFS:P07806 | caspase 12 (gene/pseudogene); Protien | Protien | n/a |