Symbol: Name: ID: |
CASP3 caspase 3, apoptosis-related cysteine peptidase GFS:4322 |
Gene name: | CASP3 |
Chromosome: | 4q34 |
Previous Symbols: | |
Previous Names: | caspase 3, apoptosis-related cysteine protease |
Aliases: | CPP32, CPP32B, Yama, apopain |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:107739 | Rat Genome Database ID: | RGD:2275 |
HGNC ID: | HGNC:1504 | RefSeq IDs: | NM_004346 |
Entrez Gene ID: | 836 | Ensembl Gene ID: | ENSG00000164305 |
VEGA IDs: | OTTHUMG00000133681 | UniProt ID: | P42574 |
UCSC ID: | uc003iwi.2 | OMIM ID: | 600636 |
Pubmed: | PMID8780721 | ||
CCDS IDs: | CCDSCCDS3836.1 |
Caspase 3 is a caspase protein that interacts with caspase 8 and caspase 9. It is encoded by the CASP3 gene.
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq, Jul 2008].
Function: Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp- -Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin.
Products for CASP3 gene
Catalog | Product Name | Application | Company |
GFS:E04322 | caspase 3, apoptosis-related cysteine peptidase; ELISA kit | ELISA | n/a |
GFS:A04322 | caspase 3, apoptosis-related cysteine peptidase; Anti | ANTIBODIES | n/a |
GFS:P04322 | caspase 3, apoptosis-related cysteine peptidase; Protien | Protien | n/a |