Symbol: Name: ID: |
CASP7 caspase 7, apoptosis-related cysteine peptidase GFS:4346 |
Gene name: | CASP7 |
Chromosome: | 10q25 |
Previous Symbols: | |
Previous Names: | caspase 7, apoptosis-related cysteine protease |
Aliases: | MCH3, CMH-1, ICE-LAP3 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:109383 | Rat Genome Database ID: | RGD:620944 |
HGNC ID: | HGNC:1508 | RefSeq IDs: | NM_001227 |
Entrez Gene ID: | 840 | Ensembl Gene ID: | ENSG00000165806 |
VEGA IDs: | OTTHUMG00000019076 | UniProt ID: | P55210 |
UCSC ID: | uc001lao.2 | OMIM ID: | 601761 |
Pubmed: | PMID8521391 PMID 8576161 | ||
CCDS IDs: | CCDSCCDS7580.1 CCDS CCDS7581.1 CCDS CCDS7582.1 |
Caspase-7, apoptosis-related cysteine peptidase, also known as CASP7, is a human protein encoded by the CASP7 gene.
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. The precursor of this caspase is cleaved by caspase 3 and 10. It is activated upon cell death stimuli and induces apoptosis. Alternative splicing results in four transcript variants, encoding three distinct isoforms. [provided by RefSeq, Jul 2008].
Function: Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp- -Gly-217' bond. Overexpression promotes programmed cell death.
Products for CASP7 gene
Catalog | Product Name | Application | Company |
GFS:E04346 | caspase 7, apoptosis-related cysteine peptidase; ELISA kit | ELISA | n/a |
GFS:A04346 | caspase 7, apoptosis-related cysteine peptidase; Anti | ANTIBODIES | n/a |
GFS:P04346 | caspase 7, apoptosis-related cysteine peptidase; Protien | Protien | n/a |