Symbol: Name: ID: |
CASP6 caspase 6, apoptosis-related cysteine peptidase GFS:4339 |
Gene name: | CASP6 |
Chromosome: | 4q25 |
Previous Symbols: | |
Previous Names: | caspase 6, apoptosis-related cysteine protease |
Aliases: | MCH2 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1312921 | Rat Genome Database ID: | RGD:70967 |
HGNC ID: | HGNC:1507 | RefSeq IDs: | NM_001226 |
Entrez Gene ID: | 839 | Ensembl Gene ID: | ENSG00000138794 |
VEGA IDs: | OTTHUMG00000131914 | UniProt ID: | P55212 |
UCSC ID: | uc003hzn.1 | OMIM ID: | 601532 |
Pubmed: | PMID8780721 PMID 7796396 | ||
CCDS IDs: | CCDSCCDS3684.1 CCDS CCDS3685.1 |
Caspase-6 is an enzyme that in humans is encoded by the CASP6 gene.
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in two transcript variants that encode different isoforms. [provided by RefSeq, Jul 2008].
Function: Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly(ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death.
Products for CASP6 gene
Catalog | Product Name | Application | Company |
GFS:E04339 | caspase 6, apoptosis-related cysteine peptidase; ELISA kit | ELISA | n/a |
GFS:A04339 | caspase 6, apoptosis-related cysteine peptidase; Anti | ANTIBODIES | n/a |
GFS:P04339 | caspase 6, apoptosis-related cysteine peptidase; Protien | Protien | n/a |