Symbol: Name: ID: |
USP9Y ubiquitin specific peptidase 9, Y-linked GFS:2413 |
Gene name: | USP9Y |
Chromosome: | Yq11.2 |
Previous Symbols: | |
Previous Names: | ubiquitin specific peptidase 9, Y-linked (fat facets-like, Drosophila) |
Aliases: | DFFRY |
Name Aliases: | fat facets-like homolog (Drosophila) |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1313274 | Rat Genome Database ID: | |
HGNC ID: | HGNC:12633 | RefSeq IDs: | NM_004654 |
Entrez Gene ID: | 8287 | Ensembl Gene ID: | ENSG00000114374 |
VEGA IDs: | OTTHUMG00000036469 | UniProt ID: | O00507 |
UCSC ID: | uc004fst.1 | OMIM ID: | 400005 |
Pubmed: | PMID8922996 PMID 9384609 PMID 19246359 | ||
CCDS IDs: | CCDSCCDS14781.1 |
Ubiquitin specific peptidase 9, Y-linked (fat facets-like, Drosophila), also known as USP9Y, is an enzyme which in humans is encoded by the USP9Y gene.
This gene is a member of the peptidase C19 family. It encodes a protein that is similar to ubiquitin-specific proteases, which cleave the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: May function as a ubiquitin-protein or polyubiquitin hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important role regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Essential component of TGF-beta/BMP signaling cascade. Deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF-beta/BMP signaling cascade. Deubiqitination of SMAD4 by USP9X re-empowers its competence to mediate TGF-beta signaling (By similarity).
Products for USP9Y gene
Catalog | Product Name | Application | Company |
GFS:E02413 | ubiquitin specific peptidase 9, Y-linked; ELISA kit | ELISA | n/a |
GFS:A02413 | ubiquitin specific peptidase 9, Y-linked; Anti | ANTIBODIES | n/a |
GFS:P02413 | ubiquitin specific peptidase 9, Y-linked; Protien | Protien | n/a |