Symbol: Name: ID: |
USP10 ubiquitin specific peptidase 10 GFS:2387 |
Gene name: | USP10 |
Chromosome: | 16q |
Previous Symbols: | |
Previous Names: | ubiquitin specific protease 10 |
Aliases: | UBPO, KIAA0190 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:894652 | Rat Genome Database ID: | RGD:1561965 |
HGNC ID: | HGNC:12608 | RefSeq IDs: | NM_005153 |
Entrez Gene ID: | 9100 | Ensembl Gene ID: | ENSG00000103194 |
VEGA IDs: | UniProt ID: | Q14694 | |
UCSC ID: | uc002fii.2 | OMIM ID: | 609818 |
Pubmed: | PMID12838346 | ||
CCDS IDs: | CCDSCCDS45537.1 |
Ubiquitin specific peptidase 10, also known as USP10, is an enzyme which in humans is encoded by the USP10 gene.
Ubiquitin is a highly conserved protein that is covalently linked to other proteins to regulate their function and degradation. This gene encodes a member of the ubiquitin-specific protease family of cysteine proteases. The enzyme specifically cleaves ubiquitin from ubiquitin-conjugated protein substrates. The protein is found in the nucleus and cytoplasm. It functions as a co-factor of the DNA-bound androgen receptor complex, and is inhibited by a protein in the Ras-GTPase pathway. The human genome contains several pseudogenes similar to this gene. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Hydrolase that can remove conjugated ubiquitin from target proteins such as p53/TP53, SNX3 and CFTR. Acts as an essential regulator of p53/TP53 stability: in unstressed cells, specifically deubiquitinates p53/TP53 in the cytoplasm, leading to counteract MDM2 action and stabilize p53/TP53. Following DNA damage, translocates to the nucleus and deubiquitinates p53/TP53, leading to regulate the p53/TP53-dependent DNA damage response. Does not deubiquitinate MDM2. Deubiquitinates CFTR in early endosomes, enhancing its endocytic recycling.
Products for USP10 gene
Catalog | Product Name | Application | Company |
GFS:E02387 | ubiquitin specific peptidase 10; ELISA kit | ELISA | n/a |
GFS:A02387 | ubiquitin specific peptidase 10; Anti | ANTIBODIES | n/a |
GFS:P02387 | ubiquitin specific peptidase 10; Protien | Protien | n/a |