Symbol: Name: ID: |
USP21 ubiquitin specific peptidase 21 GFS:2400 |
Gene name: | USP21 |
Chromosome: | 1q22 |
Previous Symbols: | USP23 |
Previous Names: | ubiquitin specific protease 21 |
Aliases: | USP16 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1353665 | Rat Genome Database ID: | |
HGNC ID: | HGNC:12620 | RefSeq IDs: | NM_001014443 |
Entrez Gene ID: | 27005 | Ensembl Gene ID: | ENSG00000143258 |
VEGA IDs: | OTTHUMG00000033154 | UniProt ID: | Q9UK80 |
UCSC ID: | uc010pkf.1 | OMIM ID: | 604729 |
Pubmed: | PMID12838346 PMID 10799498 | ||
CCDS IDs: | CCDSCCDS30920.1 |
This gene encodes a member of the C19 peptidase family, also known as family 2 of ubiquitin carboxy-terminal hydrolases. The encoded protein cleaves ubiquitin from ubiquitinated proteins for recycling in intracellular protein degradation. The encoded protein is also able to release NEDD8, a ubiquitin-like protein, from NEDD8-conjugated proteins. This gene has been referred to as USP16 and USP23 but is now known as USP21. Alternatively spliced transcript variants have been described. [provided by RefSeq].
Function: Deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A releaves the repression of di- and trimethylation of histone H3 at 'Lys-4', resulting in regulation of transcriptional initiation. Regulates gene expression via histone H2A deubiquitination (By similarity). Also capable of removing NEDD8 from NEDD8 conjugates but has no effect on Sentrin-1 conjugates.
Products for USP21 gene
Catalog | Product Name | Application | Company |
GFS:E02400 | ubiquitin specific peptidase 21; ELISA kit | ELISA | n/a |
GFS:A02400 | ubiquitin specific peptidase 21; Anti | ANTIBODIES | n/a |
GFS:P02400 | ubiquitin specific peptidase 21; Protien | Protien | n/a |