Symbol: Name: ID: |
USP1 ubiquitin specific peptidase 1 GFS:2386 |
Gene name: | USP1 |
Chromosome: | 1p31.3 |
Previous Symbols: | |
Previous Names: | ubiquitin specific protease 1 |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2385198 | Rat Genome Database ID: | RGD:1306461 |
HGNC ID: | HGNC:12607 | RefSeq IDs: | NM_001017415 |
Entrez Gene ID: | 7398 | Ensembl Gene ID: | ENSG00000162607 |
VEGA IDs: | OTTHUMG00000008972 | UniProt ID: | O94782 |
UCSC ID: | uc001dak.1 | OMIM ID: | 603478 |
Pubmed: | PMID12838346 | ||
CCDS IDs: | CCDSCCDS621.1 |
Ubiquitin carboxyl-terminal hydrolase 1 is an enzyme that in humans is encoded by the USP1 gene.
This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. The protein specifically deubiquitinates a protein in the Fanconi anemia (FA) DNA repair pathway. Alternate transcriptional splice variants have been characterized. [provided by RefSeq].
Function: Negative regulator of DNA damage repair which specifically deubiquitinates monoubiquitinated FANCD2. Also involved in PCNA-mediated translesion synthesis (TLS) by deubiquitinating monoubiquitinated PCNA. Has almost no deubiquitinating activity by itself and requires the interaction with WDR48 to have a high activity.
Products for USP1 gene
Catalog | Product Name | Application | Company |
GFS:E02386 | ubiquitin specific peptidase 1; ELISA kit | ELISA | n/a |
GFS:A02386 | ubiquitin specific peptidase 1; Anti | ANTIBODIES | n/a |
GFS:P02386 | ubiquitin specific peptidase 1; Protien | Protien | n/a |