Symbol: Name: ID: |
USP2 ubiquitin specific peptidase 2 GFS:2397 |
Gene name: | USP2 |
Chromosome: | 11q23.3 |
Previous Symbols: | |
Previous Names: | ubiquitin specific protease 2 |
Aliases: | UBP41 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1858178 | Rat Genome Database ID: | RGD:621073 |
HGNC ID: | HGNC:12618 | RefSeq IDs: | NM_004205 |
Entrez Gene ID: | 9099 | Ensembl Gene ID: | ENSG00000036672 |
VEGA IDs: | UniProt ID: | O75604 | |
UCSC ID: | uc001pwm.3 | OMIM ID: | 604725 |
Pubmed: | PMID12838346 | ||
CCDS IDs: | CCDSCCDS8422.1 CCDS CCDS8423.1 |
Ubiquitin carboxyl-terminal hydrolase 2 is an enzyme that in humans is encoded by the USP2 gene.
Ubiquitin (MIM 191339), a highly conserved protein involved in the regulation of intracellular protein breakdown, cell cycle regulation, and stress response, is released from degraded proteins by disassembly of the polyubiquitin chains. The disassembly process is mediated by ubiquitin-specific proteases (USPs). Also see USP1 (MIM 603478).[supplied by OMIM].
Function: Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Isoform 1 and isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4. Plays a role in the G1/S cell-cycle progression in normal and cancer cells. Plays a role in the regulation of myogenic differentiation of embryonic muscle cells.
Products for USP2 gene
Catalog | Product Name | Application | Company |
GFS:E02397 | ubiquitin specific peptidase 2; ELISA kit | ELISA | n/a |
GFS:A02397 | ubiquitin specific peptidase 2; Anti | ANTIBODIES | n/a |
GFS:P02397 | ubiquitin specific peptidase 2; Protien | Protien | n/a |