Symbol: Name: ID: |
USP14 ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) GFS:2391 |
Gene name: | USP14 |
Chromosome: | 18p11.32 |
Previous Symbols: | |
Previous Names: | ubiquitin specific protease 14 (tRNA-guanine transglycosylase) |
Aliases: | TGT |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1928898 | Rat Genome Database ID: | RGD:1311825 |
HGNC ID: | HGNC:12612 | RefSeq IDs: | NM_001037334 |
Entrez Gene ID: | 9097 | Ensembl Gene ID: | ENSG00000101557 |
VEGA IDs: | UniProt ID: | P54578 | |
UCSC ID: | uc002kkf.1 | OMIM ID: | 607274 |
Pubmed: | PMID12838346 | ||
CCDS IDs: | CCDSCCDS32780.1 CCDS CCDS32781.1 |
Ubiquitin carboxyl-terminal hydrolase 14 is an enzyme that in humans is encoded by the USP14 gene.
This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. Mice with a mutation that results in reduced expression of the ortholog of this protein are retarded for growth, develop severe tremors by 2 to 3 weeks of age followed by hindlimb paralysis and death by 6 to 10 weeks of age. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq].
Function: Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. Indispensable for synaptic development and function at neuromuscular junctions (NMJs).
Products for USP14 gene
Catalog | Product Name | Application | Company |
GFS:E02391 | ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase); ELISA kit | ELISA | n/a |
GFS:A02391 | ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase); Anti | ANTIBODIES | n/a |
GFS:P02391 | ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase); Protien | Protien | n/a |