Symbol: Name: ID: |
USP20 ubiquitin specific peptidase 20 GFS:2398 |
Gene name: | USP20 |
Chromosome: | 9q34.2 |
Previous Symbols: | |
Previous Names: | ubiquitin specific protease 20 |
Aliases: | KIAA1003 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1921520 | Rat Genome Database ID: | RGD:1305621 |
HGNC ID: | HGNC:12619 | RefSeq IDs: | NM_001008563 |
Entrez Gene ID: | 10868 | Ensembl Gene ID: | ENSG00000136878 |
VEGA IDs: | OTTHUMG00000020793 | UniProt ID: | Q9Y2K6 |
UCSC ID: | uc004byr.2 | OMIM ID: | |
Pubmed: | PMID12838346 | ||
CCDS IDs: | CCDSCCDS43892.1 |
Ubiquitin carboxyl-terminal hydrolase 20 is an enzyme that in humans is encoded by the USP20 gene.
Function: Deubiquitinating enzyme involved in beta-2 adrenergic receptor (ADRB2) recycling. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, possibly leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Deubiquitinates HIF1A, leading to stabilize HIF1A and enhance HIF1A-mediated activity. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.
Products for USP20 gene
Catalog | Product Name | Application | Company |
GFS:E02398 | ubiquitin specific peptidase 20; ELISA kit | ELISA | n/a |
GFS:A02398 | ubiquitin specific peptidase 20; Anti | ANTIBODIES | n/a |
GFS:P02398 | ubiquitin specific peptidase 20; Protien | Protien | n/a |