Symbol: Name: ID: |
USP25 ubiquitin specific peptidase 25 GFS:2403 |
Gene name: | USP25 |
Chromosome: | 21q11.2 |
Previous Symbols: | |
Previous Names: | ubiquitin specific protease 25 |
Aliases: | USP21 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1353655 | Rat Genome Database ID: | RGD:1309003 |
HGNC ID: | HGNC:12624 | RefSeq IDs: | NM_013396 |
Entrez Gene ID: | 29761 | Ensembl Gene ID: | ENSG00000155313 |
VEGA IDs: | OTTHUMG00000074343 | UniProt ID: | Q9UHP3 |
UCSC ID: | uc002yjy.1 | OMIM ID: | 604736 |
Pubmed: | PMID12838346 PMID 10612803 | ||
CCDS IDs: | CCDSCCDS33515.1 |
Ubiquitin (MIM 191339) is a highly conserved 76-amino acid protein involved in regulation of intracellular protein breakdown, cell cycle regulation, and stress response. Ubiquitin is released from degraded proteins by disassembly of the polyubiquitin chains, which is mediated by ubiquitin-specific proteases (USPs), such as USP25 (Valero et al., 1999 [PubMed 10644437]).[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions to process newly synthesized Ubiquitin, to recycle ubiquitin molecules or to edit polyubiquitin chains and prevents proteasomal degradation of substrates. Hydrolyzes both 'Lys-48'- and 'Lys-63'-linked tetraubiquitin chains .
Function: The muscle-specific isoform (USP25m) may have a role in the regulation of muscular differentiation and function.
Products for USP25 gene
Catalog | Product Name | Application | Company |
GFS:E02403 | ubiquitin specific peptidase 25; ELISA kit | ELISA | n/a |
GFS:A02403 | ubiquitin specific peptidase 25; Anti | ANTIBODIES | n/a |
GFS:P02403 | ubiquitin specific peptidase 25; Protien | Protien | n/a |