Symbol: Name: ID: |
USP9X ubiquitin specific peptidase 9, X-linked GFS:2412 |
Gene name: | USP9X |
Chromosome: | Xp11.4 |
Previous Symbols: | |
Previous Names: | ubiquitin specific protease 9, X chromosome (fat facets-like Drosophila), "ubiquitin specific protease 9, X-linked (fat facets-like, Drosophila)", "ubiquitin specific peptidase 9, X-linked (fat facets-like, Drosophila)" |
Aliases: | DFFRX, FAF |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:894681 | Rat Genome Database ID: | RGD:1560056 |
HGNC ID: | HGNC:12632 | RefSeq IDs: | NM_001039590 |
Entrez Gene ID: | 8239 | Ensembl Gene ID: | ENSG00000124486 |
VEGA IDs: | OTTHUMG00000021367 | UniProt ID: | Q93008 |
UCSC ID: | uc004dfb.2 | OMIM ID: | 300072 |
Pubmed: | PMID8922996 | ||
CCDS IDs: | CCDSCCDS43930.1 |
Probable ubiquitin carboxyl-terminal hydrolase FAF-X is an enzyme that in humans is encoded by the USP9X gene.
This gene is a member of the peptidase C19 family and encodes a protein that is similar to ubiquitin-specific proteases. Though this gene is located on the X chromosome, it escapes X-inactivation. Mutations in this gene have been associated with Turner syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq].
Function: Deubiquitinase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important role regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Essential component of TGF-beta/BMP signaling cascade. Regulates chromosome alignment and segregation in mitosis by regulating the localization of BIRC5/survivin to mitotic centromeres. Specifically hydrolyzes both 'Lys-29'- and 'Lys-33'-linked polyubiquitins chains. Specifically deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33.
Products for USP9X gene
Catalog | Product Name | Application | Company |
GFS:E02412 | ubiquitin specific peptidase 9, X-linked; ELISA kit | ELISA | n/a |
GFS:A02412 | ubiquitin specific peptidase 9, X-linked; Anti | ANTIBODIES | n/a |
GFS:P02412 | ubiquitin specific peptidase 9, X-linked; Protien | Protien | n/a |