Symbol: Name: ID: |
USP8 ubiquitin specific peptidase 8 GFS:2411 |
Gene name: | USP8 |
Chromosome: | 15q21.1 |
Previous Symbols: | |
Previous Names: | ubiquitin specific protease 8 |
Aliases: | HumORF8, KIAA0055, UBPY |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1934029 | Rat Genome Database ID: | RGD:1304979 |
HGNC ID: | HGNC:12631 | RefSeq IDs: | NM_001128610 |
Entrez Gene ID: | 9101 | Ensembl Gene ID: | ENSG00000138592 |
VEGA IDs: | OTTHUMG00000131645 | UniProt ID: | P40818 |
UCSC ID: | uc001zyl.3 | OMIM ID: | 603158 |
Pubmed: | PMID12838346 PMID 9582025 | ||
CCDS IDs: | CCDSCCDS10137.1 |
Ubiquitin carboxyl-terminal hydrolase 8 is an enzyme that in humans is encoded by the USP8 gene.
Function: Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controles tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules.
Products for USP8 gene
Catalog | Product Name | Application | Company |
GFS:E02411 | ubiquitin specific peptidase 8; ELISA kit | ELISA | n/a |
GFS:A02411 | ubiquitin specific peptidase 8; Anti | ANTIBODIES | n/a |
GFS:P02411 | ubiquitin specific peptidase 8; Protien | Protien | n/a |