Symbol: Name: ID: |
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) GFS:2410 |
Gene name: | USP7 |
Chromosome: | 16p13.3 |
Previous Symbols: | HAUSP |
Previous Names: | ubiquitin specific protease 7 (herpes virus-associated) |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2182061 | Rat Genome Database ID: | RGD:1306915 |
HGNC ID: | HGNC:12630 | RefSeq IDs: | NM_003470 |
Entrez Gene ID: | 7874 | Ensembl Gene ID: | ENSG00000187555 |
VEGA IDs: | UniProt ID: | Q93009 | |
UCSC ID: | uc002czl.2 | OMIM ID: | 602519 |
Pubmed: | PMID12838346 PMID 9925944 | ||
CCDS IDs: | CCDSCCDS32385.1 |
Ubiquitin-specific-processing protease 7 (USP7) also known as ubiquitin carboxyl-terminal hydrolase 7 or herpesvirus-associated ubiquitin-specific protease (HAUSP) is an enzyme that in humans is encoded by the USP7 gene.
Function: Hydrolase that deubiquitinates target proteins such as FOXO4, p53/TP53, MDM2, PTEN and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation. Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, and also induces p53/TP53-dependent cell growth repression and apoptosis. Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on p53/TP53 and inhibits FOXO4-induced transcriptional activity. In association with DAXX, is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, both processes that are counteracted by PML. Involved in cell proliferation during early embryonic development. Contributes to the overall stabilization and trans-activation capability of the herpesvirus 1 trans-acting transcriptional protein ICP0/VMW110 during HSV-1 infection.
Products for USP7 gene
Catalog | Product Name | Application | Company |
GFS:E02410 | ubiquitin specific peptidase 7 (herpes virus-associated); ELISA kit | ELISA | n/a |
GFS:A02410 | ubiquitin specific peptidase 7 (herpes virus-associated); Anti | ANTIBODIES | n/a |
GFS:P02410 | ubiquitin specific peptidase 7 (herpes virus-associated); Protien | Protien | n/a |