Symbol: Name: ID: |
USP6 ubiquitin specific peptidase 6 (Tre-2 oncogene) GFS:2408 |
Gene name: | USP6 |
Chromosome: | 17p13 |
Previous Symbols: | HRP1 |
Previous Names: | ubiquitin specific protease 6 (Tre-2 oncogene) |
Aliases: | Tre-2, TRE17, Tre2 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | Rat Genome Database ID: | ||
HGNC ID: | HGNC:12629 | RefSeq IDs: | NM_004505 |
Entrez Gene ID: | 9098 | Ensembl Gene ID: | ENSG00000129204 |
VEGA IDs: | OTTHUMG00000099449 | UniProt ID: | P35125 |
UCSC ID: | uc002gav.1 | OMIM ID: | 604334 |
Pubmed: | PMID12838346 PMID 1349106 | ||
CCDS IDs: | CCDSCCDS11069.2 |
Ubiquitin carboxyl-terminal hydrolase 6 is an enzyme that in humans is encoded by the USP6 gene.
Function: Deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Catalyzes its own deubiquitination. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity. Promotes plasma membrane localization of ARF6 and selectively regulates ARF6-dependent endocytic protein trafficking. Is able to initiate tumorigenesis by inducing the production of matrix metalloproteinases following NF-kappa-B activation.
Products for USP6 gene
Catalog | Product Name | Application | Company |
GFS:E02408 | ubiquitin specific peptidase 6 (Tre-2 oncogene); ELISA kit | ELISA | n/a |
GFS:A02408 | ubiquitin specific peptidase 6 (Tre-2 oncogene); Anti | ANTIBODIES | n/a |
GFS:P02408 | ubiquitin specific peptidase 6 (Tre-2 oncogene); Protien | Protien | n/a |