Symbol: Name: ID: |
USP5 ubiquitin specific peptidase 5 (isopeptidase T) GFS:2407 |
Gene name: | USP5 |
Chromosome: | 12p13 |
Previous Symbols: | |
Previous Names: | ubiquitin specific protease 5 (isopeptidase T) |
Aliases: | IsoT |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1347343 | Rat Genome Database ID: | RGD:1308438 |
HGNC ID: | HGNC:12628 | RefSeq IDs: | NM_001098536 |
Entrez Gene ID: | 8078 | Ensembl Gene ID: | ENSG00000111667 |
VEGA IDs: | UniProt ID: | P45974 | |
UCSC ID: | uc001qri.3 | OMIM ID: | 601447 |
Pubmed: | PMID12838346 PMID 8723724 | ||
CCDS IDs: | CCDSCCDS31733.1 CCDS CCDS41743.1 |
Ubiquitin carboxyl-terminal hydrolase 5 is an enzyme that in humans is encoded by the USP5 gene.
Ubiquitin (see MIM 191339)-dependent proteolysis is a complex pathway of protein metabolism implicated in such diverse cellular functions as maintenance of chromatin structure, receptor function, and degradation of abnormal proteins. A late step of the process involves disassembly of the polyubiquitin chains on degraded proteins into ubiquitin monomers. USP5 disassembles branched polyubiquitin chains by a sequential exo mechanism, starting at the proximal end of the chain (Wilkinson et al., 1995 [PubMed 7578059]).[supplied by OMIM].
Function: Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys-63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.
Products for USP5 gene
Catalog | Product Name | Application | Company |
GFS:E02407 | ubiquitin specific peptidase 5 (isopeptidase T); ELISA kit | ELISA | n/a |
GFS:A02407 | ubiquitin specific peptidase 5 (isopeptidase T); Anti | ANTIBODIES | n/a |
GFS:P02407 | ubiquitin specific peptidase 5 (isopeptidase T); Protien | Protien | n/a |