Symbol: Name: ID: |
USP48 ubiquitin specific peptidase 48 GFS:7379 |
Gene name: | USP48 |
Chromosome: | 1p36.12 |
Previous Symbols: | USP31 |
Previous Names: | ubiquitin specific protease 31, "ubiquitin specific protease 48" |
Aliases: | FLJ23277, FLJ11328, FLJ20103, FLJ23054, MGC14879 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2158502 | Rat Genome Database ID: | RGD:735213 |
HGNC ID: | HGNC:18533 | RefSeq IDs: | NM_001032730 |
Entrez Gene ID: | 84196 | Ensembl Gene ID: | ENSG00000090686 |
VEGA IDs: | OTTHUMG00000007798 | UniProt ID: | Q86UV5 |
UCSC ID: | uc001bfb.2 | OMIM ID: | |
Pubmed: | PMID12838346 | ||
CCDS IDs: | CCDSCCDS30623.1 CCDS CCDS44084.1 |
Ubiquitin carboxyl-terminal hydrolase 48 is an enzyme that in humans is encoded by the USP48 gene.
This gene encodes a protein containing domains that associate it with the peptidase family C19, also known as family 2 of ubiquitin carboxyl-terminal hydrolases. Family members function as deubiquitinating enzymes, recognizing and hydrolyzing the peptide bond at the C-terminal glycine of ubiquitin. Enzymes in peptidase family C19 are involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].
Function: Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquinated proteins. May be involved in the regulation of NF-kappa-B activation by TNF receptor superfamily via its interactions with RELA and TRAF2. May also play a regulatory role at post-synaptic sites.
Products for USP48 gene
Catalog | Product Name | Application | Company |
GFS:E07379 | ubiquitin specific peptidase 48; ELISA kit | ELISA | n/a |
GFS:A07379 | ubiquitin specific peptidase 48; Anti | ANTIBODIES | n/a |
GFS:P07379 | ubiquitin specific peptidase 48; Protien | Protien | n/a |