Symbol: Name: ID: |
TP63 tumor protein p63 GFS:5109 |
Gene name: | TP63 |
Chromosome: | 3q27-q29 |
Previous Symbols: | TP73L, TP53L, TP53CP |
Previous Names: | tumor protein p73-like, "tumor protein p53-like", "tumor protein p53-competing protein" |
Aliases: | p51, SHFM4, EEC3, p63, p73L, OFC8, KET, p73H, NBP, p53CP |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1330810 | Rat Genome Database ID: | RGD:620863 |
HGNC ID: | HGNC:15979 | RefSeq IDs: | NM_001114978 |
Entrez Gene ID: | 8626 | Ensembl Gene ID: | ENSG00000073282 |
VEGA IDs: | OTTHUMG00000156313 | UniProt ID: | Q9H3D4 |
UCSC ID: | uc003fry.2 | OMIM ID: | 603273 |
Pubmed: | PMID9774969 PMID 9662378 PMID 11181441 PMID 11181451 | ||
CCDS IDs: | CCDSCCDS3293.1 CCDS CCDS46976.1 CCDS CCDS46977.1 CCDS CCDS46978.1 CCDS CCDS46979.1 CCDS CCDS46980.1 |
Tumor protein p63 also known as transformation-related protein 63 is a protein that in humans is encoded by the TP63 gene.
This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined. [provided by RefSeq, Jul 2008].
Function: Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge.
Products for TP63 gene
Catalog | Product Name | Application | Company |
GFS:E05109 | tumor protein p63; ELISA kit | ELISA | n/a |
GFS:A05109 | tumor protein p63; Anti | ANTIBODIES | n/a |
GFS:P05109 | tumor protein p63; Protien | Protien | n/a |