Symbol: Name: ID: |
SFTPB surfactant protein B GFS:718 |
Gene name: | SFTPB |
Chromosome: | 2p12-p11.2 |
Previous Symbols: | SFTP3 |
Previous Names: | surfactant, pulmonary-associated protein B |
Aliases: | SP-B |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:109516 | Rat Genome Database ID: | RGD:621700 |
HGNC ID: | HGNC:10801 | RefSeq IDs: | NM_000542 |
Entrez Gene ID: | 6439 | Ensembl Gene ID: | ENSG00000168878 |
VEGA IDs: | OTTHUMG00000130181 | UniProt ID: | P07988 |
UCSC ID: | uc002sqh.2 | OMIM ID: | 178640 |
Pubmed: | PMID2924687 PMID 1346779 | ||
CCDS IDs: | CCDSCCDS1983.1 |
Pulmonary surfactant-associated protein B is a protein that in humans is encoded by the SFTPB gene. This gene encodes the pulmonary-associated surfactant protein B (SPB), an amphipathic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. The SPB enhances the rate of spreading and increases the stability of surfactant monolayers in vitro. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 1, also called pulmonary alveolar proteinosis due to surfactant protein B deficiency, and are associated with fatal respiratory distress in the neonatal period. Alternatively spliced transcript variants encoding the same protein have been identified.
Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter
Products for SFTPB gene
Catalog | Product Name | Application | Company |
GFS:E00718 | surfactant protein B; ELISA kit | ELISA | n/a |
GFS:A00718 | surfactant protein B; Anti | ANTIBODIES | n/a |
GFS:P00718 | surfactant protein B; Protien | Protien | n/a |