Symbol: Name: ID: |
TP53 tumor protein p53 GFS:1799 |
Gene name: | TP53 |
Chromosome: | 17p13.1 |
Previous Symbols: | |
Previous Names: | |
Aliases: | p53, LFS1 |
Name Aliases: | Li-Fraumeni syndrome |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:98834 | Rat Genome Database ID: | RGD:3889 |
HGNC ID: | HGNC:11998 | RefSeq IDs: | NM_000546 |
Entrez Gene ID: | 7157 | Ensembl Gene ID: | ENSG00000141510 |
VEGA IDs: | OTTHUMG00000142618 | UniProt ID: | P04637 |
UCSC ID: | uc002gij.2 | OMIM ID: | 191170 |
Pubmed: | PMID6396087 PMID 3456488 PMID 2047879 | ||
CCDS IDs: | CCDSCCDS11118.1 CCDS CCDS45605.1 CCDS CCDS45606.1 |
p53 (also known as protein 53 or tumor protein 53), is a tumor suppressor protein that in humans is encoded by the TP53 gene. This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mutants of p53 that frequently occur in a number of different human cancers fail to bind the consensus DNA binding site, and hence cause the loss of tumor suppressor activity. Alterations of this gene occur not only as somatic mutations in human malignancies, but also as germline mutations in some cancer-prone families with Li-Fraumeni syndrome. Multiple p53 variants due to alternative promoters and multiple alternative splicing have been found. These variants encode distinct isoforms, which can regulate p53 transcriptional activity. [provided by RefSeq].
Products for TP53 gene
Catalog | Product Name | Application | Company |
GFS:E01799 | tumor protein p53; ELISA kit | ELISA | n/a |
GFS:A01799 | tumor protein p53; Anti | ANTIBODIES | n/a |
GFS:P01799 | tumor protein p53; Protien | Protien | n/a |