Symbol: Name: ID: |
TP53BP2 tumor protein p53 binding protein, 2 GFS:1802 |
Gene name: | TP53BP2 |
Chromosome: | 1q41 |
Previous Symbols: | |
Previous Names: | tumor protein p53-binding protein, 2 |
Aliases: | PPP1R13A, ASPP2, 53BP2 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:2138319 | Rat Genome Database ID: | RGD:1305461 |
HGNC ID: | HGNC:12000 | RefSeq IDs: | NM_001031685 |
Entrez Gene ID: | 7159 | Ensembl Gene ID: | ENSG00000143514 |
VEGA IDs: | OTTHUMG00000037379 | UniProt ID: | Q13625 |
UCSC ID: | uc010pvb.1 | OMIM ID: | 602143 |
Pubmed: | PMID8668206 PMID 8016121 | ||
CCDS IDs: | CCDSCCDS1538.1 CCDS CCDS44319.1 |
Apoptosis-stimulating of p53 protein 2 (ASPP2) also known as Bcl2-binding protein (Bbp) and tumor suppressor p53-binding protein 2 (p53BP2) is a protein that in humans is encoded by the TP53BP2 gene. This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. It is localized to the perinuclear region of the cytoplasm, and regulates apoptosis and cell growth through interactions with other regulatory molecules including members of the p53 family. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq].
Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, and thereby decreases APPBP1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42.
Products for TP53BP2 gene
Catalog | Product Name | Application | Company |
GFS:E01802 | tumor protein p53 binding protein, 2; ELISA kit | ELISA | n/a |
GFS:A01802 | tumor protein p53 binding protein, 2; Anti | ANTIBODIES | n/a |
GFS:P01802 | tumor protein p53 binding protein, 2; Protien | Protien | n/a |