Symbol: Name: ID: |
SFTPA1 surfactant protein A1 GFS:713 |
Gene name: | SFTPA1 |
Chromosome: | 10q22.3 |
Previous Symbols: | SFTP1 |
Previous Names: | surfactant, pulmonary-associated protein A1 |
Aliases: | SP-A, SP-A1, COLEC4 |
Name Aliases: | surfactant, pulmonary-associated protein A1A |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | Rat Genome Database ID: | RGD:3665 | |
HGNC ID: | HGNC:10798 | RefSeq IDs: | NM_001093770 |
Entrez Gene ID: | 653509 | Ensembl Gene ID: | ENSG00000122852 |
VEGA IDs: | UniProt ID: | Q8IWL2 | |
UCSC ID: | uc009xsa.2 | OMIM ID: | 178630 |
Pubmed: | |||
CCDS IDs: | CCDSCCDS44444.1 CCDS CCDS44445.1 |
SFTPA1 encodes a lung surfactant protein that is a member of a subfamily of C-type lectins called collectins. The encoded protein binds specific carbohydrate moieties found on lipids and on the surface of microorganisms. This protein plays an essential role in surfactant homeostasis and in the defense against respiratory pathogens. Mutations in this gene are associated with idiopathic pulmonary fibrosis. Alternate splicing results in multiple transcript variants. [provided by RefSeq].
In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air-liquid interface in the alveoli of the mammalian lung and is essential for normal respiration
Products for SFTPA1 gene
Catalog | Product Name | Application | Company |
GFS:E00713 | surfactant protein A1; ELISA kit | ELISA | n/a |
GFS:A00713 | surfactant protein A1; Anti | ANTIBODIES | n/a |
GFS:P00713 | surfactant protein A1; Protien | Protien | n/a |