Symbol: Name: ID: |
SFTPC surfactant protein C GFS:719 |
Gene name: | SFTPC |
Chromosome: | 8p21 |
Previous Symbols: | SFTP2 |
Previous Names: | surfactant, pulmonary-associated protein C |
Aliases: | SP-C, PSP-C, SMDP2 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:109517 | Rat Genome Database ID: | RGD:3666 |
HGNC ID: | HGNC:10802 | RefSeq IDs: | NM_001172357 |
Entrez Gene ID: | 6440 | Ensembl Gene ID: | ENSG00000168484 |
VEGA IDs: | UniProt ID: | P11686 | |
UCSC ID: | uc003xax.3 | OMIM ID: | 178620 |
Pubmed: | PMID1859376 PMID 16709565 | ||
CCDS IDs: | CCDSCCDS43722.1 |
Pulmonary surfactant-associated protein C is a protein that in humans is encoded by the SFTPC gene. This gene encodes the pulmonary-associated surfactant protein C (SPC), an extremely hydrophobic surfactant protein essential for lung function and homeostasis after birth. Pulmonary surfactant is a surface-active lipoprotein complex composed of 90% lipids and 10% proteins which include plasma proteins and apolipoproteins SPA, SPB, SPC and SPD. The surfactant is secreted by the alveolar cells of the lung and maintains the stability of pulmonary tissue by reducing the surface tension of fluids that coat the lung. Multiple mutations in this gene have been identified, which cause pulmonary surfactant metabolism dysfunction type 2, also called pulmonary alveolar proteinosis due to surfactant protein C deficiency, and are associated with interstitial lung disease in older infants, children, and adults. Alternatively spliced transcript variants encoding different protein isoforms have been identified.
Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces.
Products for SFTPC gene
Catalog | Product Name | Application | Company |
GFS:E00719 | surfactant protein C; ELISA kit | ELISA | n/a |
GFS:A00719 | surfactant protein C; Anti | ANTIBODIES | n/a |
GFS:P00719 | surfactant protein C; Protien | Protien | n/a |