Symbol: Name: ID: |
TPH1 tryptophan hydroxylase 1 GFS:1808 |
Gene name: | TPH1 |
Chromosome: | 11p15.3-p14 |
Previous Symbols: | TPRH, TPH |
Previous Names: | tryptophan hydroxylase (tryptophan 5-monooxygenase) |
Aliases: | |
Name Aliases: | tryptophan 5-monooxygenase |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:98796 | Rat Genome Database ID: | RGD:3895 |
HGNC ID: | HGNC:12008 | RefSeq IDs: | NM_004179 |
Entrez Gene ID: | 7166 | Ensembl Gene ID: | ENSG00000129167 |
VEGA IDs: | UniProt ID: | P17752 | |
UCSC ID: | uc001mnp.2 | OMIM ID: | 191060 |
Pubmed: | PMID1463016 | ||
CCDS IDs: | CCDSCCDS7829.1 |
The TPH1 encodes a member of the aromatic amino acid hydroxylase family. The encoded protein catalyzes the first and rate limiting step in the biosynthesis of serotonin, an important hormone and neurotransmitter. Mutations in this gene have been associated with an elevated risk for a variety of diseases and disorders, including schizophrenia, somatic anxiety, anger-related traits, bipolar disorder, suicidal behavior, addictions, and others. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Products for TPH1 gene
Catalog | Product Name | Application | Company |
GFS:E01808 | tryptophan hydroxylase 1; ELISA kit | ELISA | n/a |
GFS:A01808 | tryptophan hydroxylase 1; Anti | ANTIBODIES | n/a |
GFS:P01808 | tryptophan hydroxylase 1; Protien | Protien | n/a |