Symbol: Name: ID: |
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) GFS:1487 |
Gene name: | TCF7L2 |
Chromosome: | 10q25.3 |
Previous Symbols: | TCF4 |
Previous Names: | |
Aliases: | TCF-4 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1202879 | Rat Genome Database ID: | RGD:1583621 |
HGNC ID: | HGNC:11641 | RefSeq IDs: | NM_001146274 |
Entrez Gene ID: | 6934 | Ensembl Gene ID: | ENSG00000148737 |
VEGA IDs: | OTTHUMG00000019070 | UniProt ID: | Q9NQB0 |
UCSC ID: | uc001lae.3 | OMIM ID: | 602228 |
Pubmed: | PMID1741298 | ||
CCDS IDs: | CCDSCCDS7576.1 |
Transcription factor 7-like 2 (T-cell specific, HMG-box) also known as TCF7L2 or TCF4 is a protein acting as a transcription factor. In humans this protein is encoded by the TCF7L2 gene.A variant of the protein is linked to higher risk to develop type 2 diabetes. This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.
Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine.
Products for TCF7L2 gene
Catalog | Product Name | Application | Company |
GFS:E01487 | transcription factor 7-like 2 (T-cell specific, HMG-box); ELISA kit | ELISA | n/a |
GFS:A01487 | transcription factor 7-like 2 (T-cell specific, HMG-box); Anti | ANTIBODIES | n/a |
GFS:P01487 | transcription factor 7-like 2 (T-cell specific, HMG-box); Protien | Protien | n/a |