Symbol: Name: ID: |
TCF7L1 transcription factor 7-like 1 (T-cell specific, HMG-box) GFS:1486 |
Gene name: | TCF7L1 |
Chromosome: | 2p11.2 |
Previous Symbols: | TCF3 |
Previous Names: | |
Aliases: | |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1202876 | Rat Genome Database ID: | RGD:1311671 |
HGNC ID: | HGNC:11640 | RefSeq IDs: | NM_031283 |
Entrez Gene ID: | 83439 | Ensembl Gene ID: | ENSG00000152284 |
VEGA IDs: | OTTHUMG00000130026 | UniProt ID: | Q9HCS4 |
UCSC ID: | uc002soy.2 | OMIM ID: | 604652 |
Pubmed: | PMID1741298 PMID 11085512 | ||
CCDS IDs: | CCDSCCDS1971.1 |
The TCF7L1 gene encodes a member of the T cell factor/lymphoid enhancer factor family of transcription factors. These transcription factors are activated by beta catenin, mediate the Wnt signaling pathway and are antagonized by the transforming growth factor beta signaling pathway. The encoded protein contains a high mobility group-box DNA binding domain and participates in the regulation of cell cycle genes and cellular senescence. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis (By similarity). Down-regulates NQO1, leading to increased mitomycin c resistance.
Products for TCF7L1 gene
Catalog | Product Name | Application | Company |
GFS:E01486 | transcription factor 7-like 1 (T-cell specific, HMG-box); ELISA kit | ELISA | n/a |
GFS:A01486 | transcription factor 7-like 1 (T-cell specific, HMG-box); Anti | ANTIBODIES | n/a |
GFS:P01486 | transcription factor 7-like 1 (T-cell specific, HMG-box); Protien | Protien | n/a |