Symbol: Name: ID: |
TCF7 transcription factor 7 (T-cell specific, HMG-box) GFS:1484 |
Gene name: | TCF7 |
Chromosome: | 5q31 |
Previous Symbols: | |
Previous Names: | |
Aliases: | TCF-1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:98507 | Rat Genome Database ID: | RGD:1305894 |
HGNC ID: | HGNC:11639 | RefSeq IDs: | NM_001134851 |
Entrez Gene ID: | 6932 | Ensembl Gene ID: | ENSG00000081059 |
VEGA IDs: | OTTHUMG00000129124 | UniProt ID: | P36402 |
UCSC ID: | uc003kyz.2 | OMIM ID: | 189908 |
Pubmed: | |||
CCDS IDs: | CCDSCCDS4169.1 CCDS CCDS4170.1 CCDS CCDS43362.1 CCDS CCDS47263.1 |
Transcription factor 7 is a protein that in humans is encoded by the TCF7 gene. Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1.
Products for TCF7 gene
Catalog | Product Name | Application | Company |
GFS:E01484 | transcription factor 7 (T-cell specific, HMG-box); ELISA kit | ELISA | n/a |
GFS:A01484 | transcription factor 7 (T-cell specific, HMG-box); Anti | ANTIBODIES | n/a |
GFS:P01484 | transcription factor 7 (T-cell specific, HMG-box); Protien | Protien | n/a |