Symbol: Name: ID: |
CTCFL CCCTC-binding factor (zinc finger protein)-like GFS:5363 |
Gene name: | CTCFL |
Chromosome: | 20q13.31 |
Previous Symbols: | |
Previous Names: | |
Aliases: | dJ579F20.2, BORIS, CT27 |
Name Aliases: | cancer/testis antigen 27 |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:3652571 | Rat Genome Database ID: | |
HGNC ID: | HGNC:16234 | RefSeq IDs: | NM_080618 |
Entrez Gene ID: | 140690 | Ensembl Gene ID: | ENSG00000124092 |
VEGA IDs: | OTTHUMG00000032829 | UniProt ID: | Q8NI51 |
UCSC ID: | uc002xym.2 | OMIM ID: | 607022 |
Pubmed: | |||
CCDS IDs: | CCDSCCDS13459.1 |
Transcriptional repressor CTCFL also known as BORIS (Brother of Regulator of Imprinted Sites) is a protein that in humans is encoded by the CTCFL gene.
CCCTC-binding factor (CTCF), an 11-zinc-finger factor involved in gene regulation, utilizes different zinc fingers to bind varying DNA target sites. CTCF forms methylation-sensitive insulators that regulate X-chromosome inactivation. This gene is a paralog of CTCF and appears to be expressed primarily in the cytoplasm of spermatocytes, unlike CTCF which is expressed primarily in the nucleus of somatic cells. CTCF and the protein encoded by this gene are normally expressed in a mutually exclusive pattern that correlates with resetting of methylation marks during male germ cell differentiation. [provided by RefSeq, Jul 2008]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications.
Function: Testis-specific DNA binding protein responsible for insulator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 'Arg-3' to form H4R3sme2. This probably leads to recruit de novo DNA methyltransferases at these sites (By similarity). Seems to act as tumor suppressor. In association with DNMT1 and DNMT3B, involved in activation of BAG1 gene expression by binding to its promoter. Required for dimethylation of H3 lysine 4 (H3K4me2) of MYC and BRCA1 promoters.
Products for CTCFL gene
Catalog | Product Name | Application | Company |
GFS:E05363 | CCCTC-binding factor (zinc finger protein)-like; ELISA kit | ELISA | n/a |
GFS:A05363 | CCCTC-binding factor (zinc finger protein)-like; Anti | ANTIBODIES | n/a |
GFS:P05363 | CCCTC-binding factor (zinc finger protein)-like; Protien | Protien | n/a |