Symbol: Name: ID: |
TCF4 transcription factor 4 GFS:1481 |
Gene name: | TCF4 |
Chromosome: | 18q21.1 |
Previous Symbols: | |
Previous Names: | |
Aliases: | SEF2-1B, ITF2, bHLHb19 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:98506 | Rat Genome Database ID: | RGD:69271 |
HGNC ID: | HGNC:11634 | RefSeq IDs: | NM_001083962 |
Entrez Gene ID: | 6925 | Ensembl Gene ID: | ENSG00000196628 |
VEGA IDs: | OTTHUMG00000132713 | UniProt ID: | P15884 |
UCSC ID: | uc010dph.1 | OMIM ID: | 602272 |
Pubmed: | PMID9302263 PMID 2308860 | ||
CCDS IDs: | CCDSCCDS11960.1 CCDS CCDS42438.1 |
The TCF4 gene encodes transcription factor 4, a basic helix-turn-helix transcription factor. The encoded protein recognizes an Ephrussi-box ('E-box') binding site ('CANNTG') - a motif first identified in immunoglobulin enhancers. This gene is expressed predominantly in pre-B-cells, although it is found in other tissues as well. Defects in this gene are a cause of Pitt-Hopkins syndrome. Multiple alternatively spliced transcript variants that encode different proteins have been described. [provided by RefSeq].
Transcription factor that binds to the immunoglobulin enchancer Mu-E5/KE5-motif. Binds to the E-box present in the somatostatin receptor 2 initiator element (SSTR2-INR) to activate transcription (By similarity). Preferentially binds to either 5'-ACANNTGT-3' or 5'-CCANNTGG-3'.
Products for TCF4 gene
Catalog | Product Name | Application | Company |
GFS:E01481 | transcription factor 4; ELISA kit | ELISA | n/a |
GFS:A01481 | transcription factor 4; Anti | ANTIBODIES | n/a |
GFS:P01481 | transcription factor 4; Protien | Protien | n/a |