Symbol: Name: ID: |
TCF3 transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47) GFS:1480 |
Gene name: | TCF3 |
Chromosome: | 19p13.3 |
Previous Symbols: | |
Previous Names: | |
Aliases: | E2A, ITF1, MGC129647, MGC129648, bHLHb21, VDIR |
Name Aliases: | transcription factor E2-alpha, |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:98510 | Rat Genome Database ID: | RGD:620914 |
HGNC ID: | HGNC:11633 | RefSeq IDs: | NM_001136139 |
Entrez Gene ID: | 6929 | Ensembl Gene ID: | ENSG00000071564 |
VEGA IDs: | UniProt ID: | P15923 | |
UCSC ID: | uc002ltt.3 | OMIM ID: | 147141 |
Pubmed: | PMID2308859 PMID 1967983 | ||
CCDS IDs: | CCDSCCDS12074.1 CCDS CCDS45899.1 |
Transcription factor 3 (E2A immunoglobulin enhancer-binding factors E12/E47), also known as TCF3, is a protein that in humans is encoded by the TCF3 gene. TCF3 has been shown to directly enhance Hes1 (a well-known target of Notch signaling) expression. The TCF3 gene, also called E2A, encodes 2 basic helix-loop-helix (bHLH) transcription factors, E12 and E47, through alternative splicing. E12 and E47 are involved in regulation of immunoglobulin gene expression (Bain et al., 1994 [PubMed 8001125]).[supplied by OMIM].
Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E-box motifs: 5'-CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer.
Products for TCF3 gene
Catalog | Product Name | Application | Company |
GFS:E01480 | transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47); ELISA kit | ELISA | n/a |
GFS:A01480 | transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47); Anti | ANTIBODIES | n/a |
GFS:P01480 | transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47); Protien | Protien | n/a |