Symbol: Name: ID: |
CDKN3 cyclin-dependent kinase inhibitor 3 GFS:6810 |
Gene name: | CDKN3 |
Chromosome: | 14q22 |
Previous Symbols: | |
Previous Names: | |
Aliases: | KAP, CDI1 |
Name Aliases: | cyclin-dependent kinase inhibitor, |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:1919641 | Rat Genome Database ID: | RGD:1307781 |
HGNC ID: | HGNC:1791 | RefSeq IDs: | NM_001130851 |
Entrez Gene ID: | 1033 | Ensembl Gene ID: | ENSG00000100526 |
VEGA IDs: | OTTHUMG00000140302 | UniProt ID: | Q16667 |
UCSC ID: | uc001xap.2 | OMIM ID: | 123832 |
Pubmed: | PMID8242750 PMID 7698009 | ||
CCDS IDs: | CCDSCCDS9716.1 CCDS CCDS45109.1 |
Cyclin-dependent kinase inhibitor 3 is an enzyme that in humans is encoded by the CDKN3 gene.
The protein encoded by this gene belongs to the dual specificity protein phosphatase family. It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. This gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008].
Function: May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. Dephosphorylates CDK2 at 'Thr-160' in a cyclin-dependent manner.
Products for CDKN3 gene
Catalog | Product Name | Application | Company |
GFS:E06810 | cyclin-dependent kinase inhibitor 3; ELISA kit | ELISA | n/a |
GFS:A06810 | cyclin-dependent kinase inhibitor 3; Anti | ANTIBODIES | n/a |
GFS:P06810 | cyclin-dependent kinase inhibitor 3; Protien | Protien | n/a |