Symbol: Name: ID: |
CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) GFS:6772 |
Gene name: | CDKN2A |
Chromosome: | 9p21 |
Previous Symbols: | CDKN2, MLM |
Previous Names: | |
Aliases: | CDK4I, p16, INK4a, MTS1, CMM2, ARF, p19, p14, INK4, p16INK4a, p19Arf |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:104738 | Rat Genome Database ID: | RGD:2323 |
HGNC ID: | HGNC:1787 | RefSeq IDs: | NM_000077 |
Entrez Gene ID: | 1029 | Ensembl Gene ID: | ENSG00000147889 |
VEGA IDs: | OTTHUMG00000019686 | UniProt ID: | P42771 |
UCSC ID: | uc003zpk.2 | OMIM ID: | 600160 |
Pubmed: | PMID8152487 PMID 7606716 | ||
CCDS IDs: | CCDSCCDS6510.1 CCDS CCDS6511.1 |
Cyclin-dependent kinase inhibitor 2A, (CDKN2A, p16Ink4A) also known as multiple tumor suppressor 1 (MTS-1), is a tumor suppressor protein, that in humans is encoded by the CDKN2A gene.
This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, MDM1, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Jul 2008].
Products for CDKN2A gene
Catalog | Product Name | Application | Company |
GFS:E06772 | cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4); ELISA kit | ELISA | n/a |
GFS:A06772 | cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4); Anti | ANTIBODIES | n/a |
GFS:P06772 | cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4); Protien | Protien | n/a |