Symbol: Name: ID: |
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) GFS:6740 |
Gene name: | CDKN1A |
Chromosome: | 6p21.1 |
Previous Symbols: | CDKN1 |
Previous Names: | |
Aliases: | P21, CIP1, WAF1, SDI1, CAP20, p21CIP1, p21Cip1/Waf1 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:104556 | Rat Genome Database ID: | RGD:69328 |
HGNC ID: | HGNC:1784 | RefSeq IDs: | NM_000389 |
Entrez Gene ID: | 1026 | Ensembl Gene ID: | ENSG00000124762 |
VEGA IDs: | OTTHUMG00000014603 | UniProt ID: | P38936 |
UCSC ID: | uc003omm.3 | OMIM ID: | 116899 |
Pubmed: | |||
CCDS IDs: | CCDSCCDS4824.1 |
p21 / WAF1 also known as cyclin-dependent kinase inhibitor 1 or CDK-interacting protein 1 is a protein that in humans is encoded by the CDKN1A gene located on chromosome 6 (6p21.2).
This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene. [provided by RefSeq, Nov 2010].
Function: May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex.
Products for CDKN1A gene
Catalog | Product Name | Application | Company |
GFS:E06740 | cyclin-dependent kinase inhibitor 1A (p21, Cip1); ELISA kit | ELISA | n/a |
GFS:A06740 | cyclin-dependent kinase inhibitor 1A (p21, Cip1); Anti | ANTIBODIES | n/a |
GFS:P06740 | cyclin-dependent kinase inhibitor 1A (p21, Cip1); Protien | Protien | n/a |