Symbol: Name: ID: |
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) GFS:6762 |
Gene name: | CDKN1C |
Chromosome: | 11p15.5 |
Previous Symbols: | BWCR, BWS |
Previous Names: | Beckwith-Wiedemann syndrome |
Aliases: | P57, KIP2 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:104564 | Rat Genome Database ID: | RGD:727892 |
HGNC ID: | HGNC:1786 | RefSeq IDs: | NM_000076 |
Entrez Gene ID: | 1028 | Ensembl Gene ID: | ENSG00000129757 |
VEGA IDs: | OTTHUMG00000010040 | UniProt ID: | P49918 |
UCSC ID: | uc001lws.3 | OMIM ID: | 600856 |
Pubmed: | PMID7729684 | ||
CCDS IDs: | CCDSCCDS7738.1 CCDS CCDS44519.1 |
Cyclin-dependent kinase inhibitor 1C (p57, Kip2), also known as CDKN1C, is protein which in humans is encoded by the CDKN1C imprinted gene.
This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010].
Function: Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life.
Products for CDKN1C gene
Catalog | Product Name | Application | Company |
GFS:E06762 | cyclin-dependent kinase inhibitor 1C (p57, Kip2); ELISA kit | ELISA | n/a |
GFS:A06762 | cyclin-dependent kinase inhibitor 1C (p57, Kip2); Anti | ANTIBODIES | n/a |
GFS:P06762 | cyclin-dependent kinase inhibitor 1C (p57, Kip2); Protien | Protien | n/a |