Symbol: Name: ID: |
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4) GFS:6801 |
Gene name: | CDKN2D |
Chromosome: | 19p13 |
Previous Symbols: | |
Previous Names: | |
Aliases: | INK4D, p19 |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:105387 | Rat Genome Database ID: | |
HGNC ID: | HGNC:1790 | RefSeq IDs: | NM_001800 |
Entrez Gene ID: | 1032 | Ensembl Gene ID: | ENSG00000129355 |
VEGA IDs: | UniProt ID: | P55273 | |
UCSC ID: | uc002mpa.2 | OMIM ID: | 600927 |
Pubmed: | PMID8575754 | ||
CCDS IDs: | CCDSCCDS12244.1 |
Cyclin-dependent kinase 4 inhibitor D is an enzyme that in humans is encoded by the CDKN2D gene.
The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis. Two alternatively spliced variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008].
Function: Interacts strongly with CDK4 and CDK6 and inhibits them.
Products for CDKN2D gene
Catalog | Product Name | Application | Company |
GFS:E06801 | cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4); ELISA kit | ELISA | n/a |
GFS:A06801 | cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4); Anti | ANTIBODIES | n/a |
GFS:P06801 | cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4); Protien | Protien | n/a |