Symbol: Name: ID: |
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) GFS:6780 |
Gene name: | CDKN2B |
Chromosome: | 9p21 |
Previous Symbols: | |
Previous Names: | |
Aliases: | P15, MTS2, INK4B, TP15, CDK4I, p15INK4b |
Name Aliases: | |
Locus Type: | gene with protein product |
Mouse Genome Database ID: | MGI:104737 | Rat Genome Database ID: | RGD:2324 |
HGNC ID: | HGNC:1788 | RefSeq IDs: | NM_004936 |
Entrez Gene ID: | 1030 | Ensembl Gene ID: | ENSG00000147883 |
VEGA IDs: | OTTHUMG00000019691 | UniProt ID: | P42772 |
UCSC ID: | uc003zpo.2 | OMIM ID: | 600431 |
Pubmed: | PMID8078588 | ||
CCDS IDs: | CCDSCCDS6512.1 CCDS CCDS6513.1 |
Cyclin-dependent kinase 4 inhibitor B also known as multiple tumor suppressor 2 (MTS-2) or p15INK4B is a protein that is encoded by the CDKN2B gene in humans.
This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008].
Function: Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest.
Products for CDKN2B gene
Catalog | Product Name | Application | Company |
GFS:E06780 | cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4); ELISA kit | ELISA | n/a |
GFS:A06780 | cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4); Anti | ANTIBODIES | n/a |
GFS:P06780 | cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4); Protien | Protien | n/a |